Diabetes is a disease that varies the way your body utilize sugar. The food you eat develops to sugar and this sugar travels through the blood to all parts of the body. Generally, insulin assists get sugar from the blood to the body’s cells, where it is used for energy or power in the body. When you have diabetes, your body has trouble making and/or reacts to insulin. So your body does not get the fuel it desires. And your blood sugar goes too high.

Types of Diabetes:

Type 1 or insulin-dependent diabetes mellitus (IDDM) occurs when the pancreas becomes unsuccessful to make sufficient insulin. It usually occurs in childhood or adolescence but can expand at any age. These patients need insulin each day.

Type 2 or non-insulin dependant diabetes mellitus occurs when body cells develop into resistant to insulin. This is more general among adults, particularly those who are overweight and over age 40. These people are able to manage their blood sugar levels through weight control, regular exercise and a well-balanced diet. Some people need oral medications or insulin injection to lower blood sugar.

Symptoms of Diabetes

Early Symptoms

Increased thirst, increased urination, increased appetite are the initial signs.

In type I weight loss is seen and in type II obesity is seen.

Additional Symptoms

Other possible symptoms are blurred vision, skin irritation or infection, weakness or loss of strength, and decreased healing capability.

Clinical lab test information reveal glycosuria (sugar in urine), hyperglycaemia, abnormal glucose tolerance tests.

If diabetes is not identified at the right time symptoms like fluid and electrolyte imbalance, acidosis, coma is seen.

Causes of Diabetes

Cause for IDDM

IDDM mostly outcome from a virally initiated autoimmune destruction of beta cells of the pancreas.

Cause for NIDDM

NIDDM is determined heritably and is expressed with age or other factors like obesity, diet and inactivity.

Home Remedies for Diabetes

1. Diabetes treatment with Bitter Gourd

Among the several home remedies that have proved helpful in controlling diabetes, perhaps the most vital is the use of bitter gourd. It has lately been established that bitter gourd contains a hypoglycaemic or insulin-like principle, designated as ‘plantinsulin’, which has been found precious in lowering the blood and urine sugar levels. It should, therefore, be included generously in the diet of the diabetic. For better results, the diabetic must take the juice of about four or five karelas each morning on an empty stomach. The seeds can be added to food in a powdered state. Diabetics can also use bitter gourd in the state of a decoction by boiling the pieces in water or in the form of dry powder.

2. Diabetes treatment with Indian Gooseberry

Indian gooseberry, with its high vitamin C content, is considered precious in diabetes. A tablespoon of its juice, mixed with a cup of bitter gourd juice, taken daily for two months, will arouses the islets of Langerhans, that is, the isolated group of cells that secrete the hormone insulin in the pancreas. This mixture decreases the blood sugar in diabetes.

3. Diabetes treatment with Jambul Fruit

Jambul fruit is another useful home remedy. It is regarded in customary medicine as a specific against diabetes because of its effect on the pancreas. The fruit as such, the seeds, and fruit juice are all helpful in the treatment of this disease. The seeds contain a glucoside ‘jamboline’ which is supposed to have the power to check the pathological conversion of starch into sugar in cases of increased production of glucose.

The seeds must be dried and powdered. One teaspoon of this powder should be mixed in one cup of milk or water or half a cup of curd, and taken two times daily. The internal bark of the jambul tree is also used in the treatment of diabetes. The bark is dried out and burnt. It will create an ash of white colour. This ash must be pestled in mortar, strained and bottled. The diabetic patient must be given ten grams of this ash on an empty stomach with water in the morning, and twenty grams in the afternoon, and in the evening an hour after taking meals. An equal amount of amla powder, jamun powder, and bitter gourd powder also makes a very useful remedy for diabetes. A teaspoon of this mixture once or twice a day would be efficient in checking the progress of the disease.

4. Diabetes treatment with Grapefruit

Grapefruit is a fine food in the diet of a diabetic patient. If grapefruits were eaten more generously, there would be much less diabetes. If you have sugar, use three grapefruits three times in a day. If you do not have sugar, but a propensity towards it and want to prevent it, use three a day.

5. Diabetes treatment with Fenugreek

The seeds of fenugreek have been found useful in the treatment of diabetes. Fenugreek seeds, when given in changeable doses of 25 gm to 100 gm daily, diminish reactive hyperglycaemia in diabetic patients. Levels of glucose, serum cholesterol, and triglycerides were also appreciably reduced in the diabetes patients when the seeds were consumed.

6. Diabetes treatment with Bengal Gram

Experiments have shown that the drinking of water extract of Bengal gram enhances the use of glucose in both diabetic and normal persons. When kept on a diet which incorporated liberal supplements of Bengal gram extract, the condition of tile patient improved considerably and his insulin requirement was decreased to about twenty units per day. Diabetes patients who are on a set diet which does not severely limit the intake of carbohydrates, but includes liberal amounts of Bengal gram extract, have shown significant improvement in their fasting blood sugar levels, glucose tolerance, urinary excretion of sugar, and general condition.

7. Diabetes treatment via Black Gram

For a milder sort of diabetes, two tablespoons of germinated black gram, taken with half a cup of fresh bitter gourd juice and a teaspoon of honey, is said to be valuable. It should be taken once each day for three to four months. A limit should be placed on the intake of carbohydrates. Still in severe cases, regular use of this combination, with other precautions, is helpful as a health-giving food for the prevention of various complications that may arise due to malnutrition in diabetics.

8. Diabetes treatment with Mango Leaves

The tender leaves of the mango tree are measured useful in diabetes. An infusion is prepared by soaking 15 gm of fresh leaves in 250 ml of water overnight, and squeezing them fine in the water in the moming. This filtrate should be taken every morning to manage early diabetes. As an option, the leaves should be dried in the shade, powdered and preserved for use when necessary. Half a teaspoon of this powder should be taken two times in a day.

9. Diabetes treatment via Parslane

The seeds of parslane are helpful in diabetes. A teaspoon of the seeds should be taken each day with half a cup of water for three to four months. It will raises the body’s own insulin and help in curing diabetes.

10. Diabetes treatment via Other Foods

Besides bitter gourd, certain other vegetables have been found helpful in diabetes. These comprise string beans, cucumber, onion, and garlic. Tea made of the pods of string beans is important in diabetes.



Thanks to Peter rodrick for contributing this article to our Diabetes blog:

Juvenile Diabetes Diet

To compare the role of glibenclamide and pioglitazone drugs in type 11 non- insulin dependent diabetes mellitus patients.

Authors:Raj kumar chohan,Mashori Ghulam Rasool,Bhurgri Ghulam Rasool,Shamim-u-Rehman,DahriGhulam mustafa,Anis-u-rehman.



Introduction:-



Diabetes comes from the greek word for ‘SIPHON” which one is the first term and implies for a lot of urine is made .The trm “mellitus” comes from a laton word, “met” which means “honey” and was used because the urine was sweet (Wheeler,2004)

Diabetic ketaocidosis is one of life threatening condition requiring some data hospitalization and treatment. Recognition of this condition is of almost importance, because even small delays can have an impact on survival (Nattrass, 2006). Hypoglycaemia are involved in insulin induced episodes in individuals with diabetes. Probably the major factor prescribing, insulin treated patient from achieving the glucose targets needed to prevent diabetic complications. The incidence of hypoglycaemia reflects the inadequancy of current mathods of insulin delievery which lead ot inappropriately high insulin concentration, particularly some persons after eating more foods at night onset of blindness and also a major risk factor heart disease and stroke

(Heller, 2003).



TYPES OF DIABETE MELLITUS

TYPE 1 DIABETES MELLITUS (IDDM):

Type I diabetes affect children of all ages, both sexes and all athenic groups. type 1 diabetes usually occurs by mechanisms. It is most common metabolic condition in children and adolescents (Bui, 2004). Type1diabetes is characterized by immune mediated destruction of pancreatic b -cells resulting in insulin deficiency. This results in a common biochemical end point of hyperglycaemia and risk of ketoacidosis, but the clinical presentaion varies, widely depending on the rate and degree of b -cells failure (Lambert & Bingley. 2005).

Type II diabetes mellitus (NIDDM):



Type II diabetes is a complex metabolic disorder associated with, b -cells dysfunction and with varying degree of insulin resistance primary pathogenic factors leading insulin resistance leading to type 2 diabetes and decreased insulin, secretion which arise from abnormalities with in liver, skeletal muscle and pancreatic b -cells (charles & clark, 1996).



GESTATIONAL DIABETUS MELLITUS

:

Women who develop glucose intolerance in late pregnancy and womens who with previously undiagnosed diabetes.





SECONDARY DIABETUS MELLITUS:



Secondary diabetes is due to disease of the pancreatic and endocrime system, genetic disorders, or exposure to chemical agents.

Type – I diabetes formerly known as insluin dependent diabetes mellitus (IDDM), is characterized by the destruction of the pancreatic beta cells that produces inslulin

Type – I diabetes formerly known as insulin dependent diabetes(IDDM),is characterized by the destruction of pancreatic beta cells that produces insulin.Type-1 diabetes occures most often in children and young adults but it can occures at any age.(Anderson et al 2007).

Type-11 diabetes is not straight uprward. A pancreas that does not produce enough insulin. Liver that release too much glucose,muscle cells that do not readily take in glucose.(Carren 2008)

Many genetic factors are involved in the development of diabetes.Because of new genetic methodology researchers are closers to identifying all of the cadidate gene for both non –insulin dependent and insulin dependent diabetes(Bernhard,1995).

Woman who had gestation diabetes are more likely to develop Type-11diabetes themselves.Pergnant women with diabetes are another disadvantaged group.They need much more intensive antenatal care and close monitoring of blood sugar,blood pressure and weight.(jawed2006)

Over weight children the progression of child obesity into adulthood is associated with early develop of complications, including IgpG2 diabetes and cardiovascular disease.Type diabetes is the most common clinical form of diabetes accountingforabout 90% of all cases,it is currently undergoing world wide epidemic. Type 11diabetes mellitus is caused by body’s infective use of insulin, it is often results from excess body weight and physical inactivity(WHO 2007).



PREVALACES& IINCIDENCE

:

Diabetes mellitus increases with aging, in 200 the prevalance of diabetes,it was estimated to be 0.19% people<20 years old and 8.6% in people>20 years old.There is considered geographic variation in the incidence of both type-1 and type-11 diabetes mellitus.Scavandinvian has the highest incidence of type-1 diabetes mellitus e.g in Finland, the incidence is 35/100,000 per year the pacific rim has a much lower rate in japan and china the incidence is 1 to 3/100,00 per year of type-1 diabetes mellitus, Northern Europe and the United States share an intermediate rate (8to17/100,000 per year).The prevalence of type 11 diabeties mellitus is highest in certain pacific island, intermediate in countries such as India and the United States, and relatively low in Russia and China.This variability is likely due to genetic, beharioral and enviromental factors(Power 2005).Diabettes mellitus prevalance also arises among different ethic population within a given countries it is common inall ethnic groups its prevalance increased with age and more than 5% of individuals of more than 65 years of age have diabetes mellitus (David Owerback 1988).The World wide prevalence of diabetes mellitus has risen dramatically over past two decades.The prevalence of type11 diabettes mellitus is expected, type 11 diabetes mellitus is more prevalent among Hispanies Native Americas,African,American,and Asians, pacific Islanders than in non- Hispanic whites,the incidence is essentially equal in woman and men in all populations. Type 11 diabetes is becoming increasingly common because people are living longer,and the prevalence of diabetes increases with age it is also seen more frequently now than before in young people, in association with the rising prevalenceof childhood obesity although type11 diabetes still countries with the estimated nubers of cases of diabetes in 2000and 2030.

Rank Country

2000 Individuals country with diabetes (milloins)

Country

2030 Individuals with diabtes (Million)

India

31.7

India

79.47

China

20.8

China

42.3

USA

17.7

USA

30.3

Indonesia

8.4

Indonesia

21.3

Japan

6.8

Pakistan

13.9

Pakistan

5.2

Brazil

11.3

Russian federation

4.6

Bangladesh

11.1

Brazil

4.6

Japan

8.9

Italy

4.3

Philippines

7.8

Bangladesh

3.2

Egypt

6.7

(Wareham& FOROUHI 2OO6)



DRUG TREATMENT OF DIABETIES MELLITUS

:

Biguanides lower blood glucose, they increase glucose uptake and utilize in skeletal muscle there by reducing insulin resistance, and reduce hepatic glucose production (gluconeogenesis).Lower blood glucose, addionally reduces low denisity and very low denisity lipoproteins (LDL and VLDL) respectively. Metformin has a half life of about 3 hours and is excreted unchanged in the urine.Clinically metformin used in type 2 diabetic who are obese and who fail treatment with diet alone.Adverse effects are produced dose related gastrointestinal disturbances e.g anorexia,diarrhoea,nausea,lactic acidosis rare but potentially fatal toxic effect.(Dale,2003).

Improving insulin sensitivity by activating certain genes involved in fat synthesis and carbohydrate metabolism Rosigilitazone and Piogiltazone are currently approved.Thiazolidinediones. Thiazolidinediones do not cause hypoglycemia when used alone,although they are usually taken in combination with sulfonylurease.

In some incouraging studies, thaiazolidiniones have produced very favorable effects on the heart, including reducing blood pressure and improving triglycerides and cholestrol levels including increasing HDL level,the good cholestrol. They may also block a molecule called 11 Best HSK that may play a significant role in metabolic syndrome,as well as diabetes type11. One study also sugessted that Rosiglitazone may even improve beta cells functions and so help prevent progression of diabetes.Anemia, weight gain, increased risk of fluid buildup, may worson heart failure.Troglitazone,was withdrawn after a few reports of heart failure.Liver failure abd death.Current Thiazoldinediones don not appear to pose the same effects on the liver although there have been a few reports of liver injury.

In patients with dietry failur the choice of a sulfonylurea agent or insulin therapy has been controversial and empric in favour of insulin therapy are the studies, who reported marked improvement post receptor diagnostic after intensive short term therapy in untreated type 2 diabetes mellitus (Scarlett et al,1984) Sulfonylureas further classified into two groups or generations based on their potency,duration,drug interaction,side effects profiles. Sulfonylureas enhance insulin action in cells in culture and stimulate the synthesis of glucose transporters (Jacobes et al 1998).A sulfonylurea drug should normally be the insulin secretagogue of choice, NICE (National Institute for Clinical Excellence) also recommends that a generic ,drug should be perscribed (Scsade et al1998).



RESEARCH DESIGN AND MATERIAL AND METHODS:



This study was conducted in the deprtment of Pharmacololgy and Therapeutics,Basic Medical Science Institute,Jinnah,Postgraduate Medical Centre,karachi under kind supervision od DRr:GhulamRsool Mashori,Associate Professoer and Head OF Department Of Pharmacology and Therapeutics in colloboration with Medical Outpatient Department Unit111 and Filter Clinic, Medical Department, JPMC,Karachi.

Seventy NIDDM (type-II)diabetic patients were initially enrolled in the study from the filter clinic/ out patient department Medical Unit III ,and diabetic clinic.Out of this 60 diabetic patients were associated in whole period of study, remaining 10 patients were dropped due to poor comlpiance or change in residential place.All the patients were divided in two main groups,groupI and in group II these patients were selected in this study according of inclusion and exclusion criteria.



INCLUSION CRITERIA

:



Newly diagnose patients of non Insulin Dependent Diabtes Mellitus.

Diagnsed patients of diabetes also including having no any history medication.

Having either sex of age between 30 to 60 years.

Diagnosed patients who were Non Insulin Depedent Diabetes Mellitus who were treated with Pioglitazone.

Diagnosed patients who were Non Imsulin Depedent Mellitus, who were treated with drug Glibenclamide.





EXCLUSION CRIRERIA

:



Patients suffering from blood pressure.

Patients suffering from liver disease.

Patients suffering from cardiac disease.

Pregnancies and lactating women.

Patient suffering from renal disorders.

Patients having serious complications.





MATERIAL:





Lacets.

Lancet Hlder(Abbots easy touch TM2 lot 03 Asee).

Glucometer(Medisense) optilim one touch(Abbotts).

Blood glucose nest trpis (IVD for Invitro diagnostic use (Abbott Labortries,Medisense UK Ltd,Abigngdon,Ox14ITR,Masde in UK). Stored between minimum 30?, (4°-30° C) and Maximum 40°C (39°-86°F).

Weight Machine Model No 1101 Lot No.312. TANTIATA.





DRUGS



Tab:Daonil 5 mg (Aventis Pharma)

Drug category:Sulphonylurea.

Generic Name: Glibenclamide.

MFGLIC:No.000007 RegistrationNO.000220

MFG Date:0-06

EXP Date:7-10

Lot NO:B230

Tab:piozer (Hilton Pharm) PvtLTd.

Tab:Poizer 15mg

Drug category:Thaiazolinedione.

Generic Name:Pioglitazone Hydrochloride.

MFG LIC: O.000136 Registration No.03270

MFG Date:3-06

EXP Date:3-o9

Lot No:6287

Tab: Poizer (Hilton Pharma)pvt ltd.

PARAMETERS:

Fasting Blood Sugar (FBS).

Random Blood Sugar (RBS).

Weight.

Key words:Diabetes mellitus,Non-insulin diabetes mellitus,Insulin depedent diabetes mellitus, Daonil,poizer,Insulin.



RESULTS:





Table 1



Weight and Blood Sugar level observed on baseline day 0

In group1 and group11

 

Group 1

Group 11

 

Pioglitazone n=27

Glibenclamide n=33

Weight

63.37

+ 2.25

¯

62.7

+ 15.56

¯

Fasting Blood Sugar

172.7

+ 13.32

¯

188.42

+ 12.o5

¯

Random Blood Sugar

285.11

+ 15 .532

¯

284.18

+ 17.07

¯

All Values are expressed in Means± SEM.

FIGURE-1 weight and blood sugar levels observed on baseline (day-o)



In table No shpwing the weight (KG’S) and blood sugar (msg/dl0 levels which is observed on baseline (day-0) in both groups 9group: 1 & group11)

Group: 1 Weight in (Kg’s) mean + SEM) IS 63.37±2.25 Fasting blood sugar 172.7±13.32,and Random

blood sugar 285.11±15.32



Group:11

Weight (KG’s0 (mean +SEM)62.7±1.56 Fasting blood sugar (mg/dl0 188.42±12.05, Random blood sugar is 284.18±17.03.

Figure 2: showing the weight and blood sugar levels observed in base line (day-0) in group: 1 and group 11 weight in 9kg’s) its mean values are 63.37,62.7, Fasting blood sugar in (mg/dl) is 172.71, 188.42 Random blood sugar (mg/dl) is 285.11 &284.18.

TABLE: 2

Peroidic Observation In All Parameters Group1

Goup1(Pioglitazon) n=27

 

P-value

 

Day-0

Day-45

Day-90

Day-0to45

Day-45-90

Weight

63.37

±2.25

63.63

±2.26

63.63

±2.23

>0.05

(NS)

>0.05

(NS)

Fasting blood sugar

172.7

±13.32

165.04

±8.98

153.37

±7.59

>0.05

(NS)

0.05

(NS)

Randomblood sugar

285.11

±15.32

279.78

±13.63

255.56

±12.65

>0.05

(NS)

>0.05

(NS)

All values are expressed in Mean±SEM .(NS) Non significant.









TABLE NO:2



Showing the periodic observations in all parameters in group 1 (piogiltazone) (n+27) weight P.value (day 0 to day 45)>0.05 (NS). Fasting blood sugar >0.05 (NS) Random blood sugar >0.05 (NS) P.values day 90 weight >0.05 (N.S), FBS>0.05 (N.S) 7RBS >0.05(N.S) NON SIGNIFICANT

FIGURE:2 Showing the periodic observation in all parameters in group 1 on day0 day 45& day-90.Mean values in weight (Kg) is 63.37,63.26,63.63, fbs (mg/dl) 172.7,165.04,153.37,RBS(mg/dl) 285.11,279.78,255.56.

TABLE NO3

Peroidic Observation in All Parameters Group11

 

Group 11 (Glibenclamide)

N=33

P-value

 

Day-0

Day-45

Day-90

Day-0 to 45

Day-45 to 90

Weight

62.7

±1.56

65.64

±2.10

64.55

±1.92

>0.05(NS)

0.05(NS0

Fasting blood sugar

188.42

±12.05

168.45

±10.99

140.06

±5.68

>0.05(NS)

>0.05(S)

Random blood sugar

284.18

±17.03

220.12

±13.39

170.94

±5.80

<0.005 (MS)

0.002(MS0

(s) significant, (MS) moderate significant

All values are expressed in Mean±SEM.



Table No3:



Showing the periodic observation in all parameter in goup:11, Group:11 containing drug (Glibenclamide),no of patients (n=33).It’s P-value on day 0 to day 45 on weight >0.05(NS),FBS>0.05(N.S) RBS<0.005 (MS) <0.01- AND DAY 45 TO DAY 90 WEIGHT >0.05 (NS) FBS (0.05) RBS <0.002(M.S0 moderately significant.



Figure 3:Shwing the periodic observations in all parameters in Group 11 weight 62.7,65.64,64.55,FBS (MG/DL) 188.42,168.45 140.06,RBS(mg/dl) 284.18 220.12, 170.94 (on day-0-day 45 to 90).



DISCUSSION:



In Denmark Beck-Nielsenet al,skillman TG (1981) published studies demonstation that glyburide increased he number of receptors on the monocytes of patients with type 11 diabetes mellitus. Some patients were treated with diet and in cobination of second generation sulfonyureas agents Wie. The numbers of insulin receptors all patients were measured before and after the treatment.Intrvenous glucose test shows the persistent impairent of insulin secretion afterthe starting of drug therapy.However those patient who were on drug Pioglitazone some results were obtained of insulin secretion in the impairment in early drug drug therapy.Clinical observations have suggested that the second generation sulfonylureas may exert their effects by potentiating insulin released by other primary stimulators Insulin secreting drug.

According to the study of WilliamC Dukworth et al(1972), aftr the chronic treatment with sulfonylureas it is well documented that plasma insulin levels were decreased in response to oral glucose load. This apparently occures even though glucose tolerance is improved over pre-treatment, levels,present study clearly support that study.

The result og group 11 correlates with the research conducted by Bonnie &Kimmel (2005) produces the same results as FBS reduces from baseline, and at the end of study,with an overall 23.44%,reduction,while with the results showed at the end of study peroid p-value were (p<0,001).

Similarly Michael Alvarsson et al (2003) conducted a similar type of study and the found and overall changes of change of 22.11% in Fbs and 40.88% in Rbs at the end of trial p-value were (p<0.001).

However a study conducted by (Stone &Brown in (2003) didnot match to our results in the parameter of FBS and observer a reduction of 26.22%.



CONCLUSION:



In the light of study discussion it is obiovus the glibenclamide was more effective,tolerable and safer than pioglitzone in a short duration.Diabetes Mellitus is chronic prolong disease for whole life.Poor community can afford it easily,on base of marketing of this drug in pakistan diabetes patients easily go and purchase economically,in fact ,mostly people buy it from pharmacy without dr’s perscription,because pharmacist and patient both of know about this disease.Just like dispirin as analgesic,it is famous anti-diabetic drug in our states as compared of other anti-diabetic drugs.



REFERNCES:





Anderson J,Kendall,Perryman.S etal,”Diet and Diabettes” Diabetes 2006,16(3):17-19-

Bui H- Type 1 diabetes in childhood-Medicine 2006,3 ,1-3

Bernhard –Diabetes-type 11 diabetes mellitus Diabetes care 1995,19(100:12-17-

Clark CM-Oral therapyin type11 diabetes-pharmacological properties and clinical use of current use of currently available agents-Diabetes spectrum 1998,11(4):211-221.

Carren M.Types of Diabetes mellitus-Diabettes 2006 10 (3),07-

David Owerback NJ-Prevalence in diabetes population-Diabetes 1988,02(6):31-32

Dale MM,-Treatment of Diabetes mellitus –pharmacology 20035th edition:287-391.

Heller SR –Hypoglycemic in diabetes Ketoacidosis and hypoglycemic-Medicine 2006:34(03):102-110.

Jawad F Untraveling the mystry of Diabetes’Diabetes 2006;15(3):13-15.

Jacobes D-Insulin-Diabetes 1998;6(3);1160126.

Lambert and Bingliy-basic facts-medicine 2006,34(6):3-7.

Natters M-Ketoacdosis and hyperglycemia-Medicine 2006;34(3):104-106.

Power AC-Epidemiology of type11 diabetes Basic facts of diabetes –Diabetes 2005;1(1)7-9

Scarlet Oral therapy in type 11 diabetes sulfonylureas 1984;16(10);3-9.

Schade DS et al A placebo controlled randomized study of glimepiride in patients of Diabetes mellitus- Diabetes 19998, 38(7);636-641.

Warchman and Forouhi-Epidimology of Diabetes- Diabetes basic facts- Medicine 2006 ;34(2);57-60

Wheeler Gd- Aaccident dicovery led to the noble prize for canadian reseachers,2005,01-02.

WHO Report-Health-Diabetes Mellitus-Defiition and types of Diabetes 2007;1:1-4.





Thanks to lalaghulamrasool bhurgri for contributing this article to our Diabetes blog:

Get a Money-making Website

Diabetes is a hormone disorder that can cause problems with the kidneys, legs and feet, eyes, heart, nerves, and blood flow.Diabetes can cause many complications. Acute complications (hypoglycemia, ketoacidosis or nonketotic hyperosmolar coma) may occur if the disease is not adequately controlled. Diabetes is on the increase, probably because people are living longer, getting fatter and leading increasingly inactive lifestyles. Diabetes, without qualification, usually refers to diabetes mellitus, but there are several rarer conditions also named diabetes. The most common of these is diabetes insipidus in which the urine is not sweet; it can be caused by either kidney or pituitary gland damage. The term “type 1 diabetes” has universally replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes. “Type 2 diabetes” has also replaced several older terms, including adult-onset diabetes, obesity-related diabetes, and non-insulin-dependent diabetes. About 3 to 8 percent of pregnant women in the United States develop gestational diabetes.

Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. Type 1 diabetes mellitus—formerly known as insulin-dependent diabetes (IDDM), childhood diabetes. Type 2 diabetes mellitus—previously known as adult-onset diabetes, maturity-onset diabetes, or non-insulin-dependent diabetes mellitus (NIDDM). Symptoms of Type 2 diabetes may include fatigue, thirst, weight loss, blurred vision and frequent urination. Some people have no symptoms. A blood test can show if you have diabetes. Exercise, weight control and sticking to your meal plan can help control your diabetes. Most people affected by type 1 diabetes are otherwise healthy and of a healthy weight when onset occurs. Diet and exercise cannot reverse or prevent type 1 diabetes. Gestational diabetes is caused by the hormones of pregnancy or a shortage of insulin. Women with gestational diabetes may not experience any symptoms.

Diabetes mellitus is characterized by recurrent or persistent hyperglycemia. Diabetes affects more than 20 million Americans. About 54 million Americans have prediabetes. Medications have also been shown to provide similar benefit. Both diabetes drugs metformin and Precose have been shown to prevent the onset of type 2 diabetes in people with this pre-diabetes condition. A group of medicines known as ACE (angiotensin converting enzyme) inhibitors are sometimes used to reduce the risk of developing cardiovascular complications in diabetes and can also reduce the risk or progression of kidney and eye diseases. Microscopic or nanotechnological approaches are under investigation as well, in one proposed case with implanted stores of insulin metered out by a rapid response valve sensitive to blood glucose levels. Medications to treat diabetes include insulin and glucose-lowering pills called oral hypoglycemic drugs. Insulin preparations differ in how quickly they start to work and how long they remain active. Stop smoking, which hinders blood flow to the feet.

Diabetes Treatment and Prevention Tips

1. Diabetes is usually controlled by a healthy diet and regular exercise.

2. Magnesium may play a significant role in preventing Type 2 diabetes.

3. Use of metformin, rosiglitazone and valsartan.

4. Exercise, weight control and sticking to your meal plan can help control your diabetes.

5. Glucose in the blood is produced by the liver from the foods you eat.

6. Oral medications are still insufficient, insulin medications are considered.

7. Maintaining an ideal body weight and an active lifestyle may prevent the onset of type 2 diabetes.

8. Strict control of blood glucose, or blood sugar, as well as blood pressure



Thanks to Juliet Cohen for contributing this article to our Diabetes blog:

Best Blood Glucose Monitor

Diabetes is considered a serios affection due to its permanent existence, procedures and moreover the complications that involves. Even though many people all over the world suffer from diabetes, the specialists haven t discovered yet the real source of its occurance. It is very important to mention that people who suffer from diabets should ask for medical help as soon as they notice changes in their body and unusual symptoms.

First of all, diabetes occurs when the beta cells in the pancreas which produce insulin are totally destroyed. As we know the food that we eat turns into glucose or sugar helping our body to use for energy. Once there aren’ t beta cells to produce insulin in order to transfer the glucose in the cells, the sugar remains in the blood and because the body cannot use sugar, it is spilled over into the urine and lost. Much more, diabetes can lead to severe health complications, such as heart disease, kidney failure, blindless, lower-extremity amputations and in many cases even death.

Secondly, people who notice certain symptoms which indicate the presence of diabetes should see a physician in order to receive a proper diagnosis. Some of the most common symtoms which indicate the presence of diabetes are: excessive hunger and thirst, frequent urination, dramatic weight loss, lack of energy, dry skin, wounds that heal very hard and even nausea and stomach pains, symptoms which usually occur in type 1 diabetes.

In addition to this, there are two types of diabetes which are quoted from the National Diabetes Fact Sheet: National estimates and general information on diabetes in the United States (Centers for Disease Control an Prevention. Atlanta, GA: US Department of Health and Human Services, 1997). Much more, type 1 diabetes tends to be more serios than type 2 diabetes and usually occurs during the childhood.

Type 1 diabetes also called insulin-dependent diabetes mellitus (IDDM) or Juvenile-Onset diabetes, is a common disease in children and may account for 5% to 10% of all diagnosed cases of diabetes. The factors which cause type 1 diabetes aren t entirely known but it has been considered that genetic predisposition and enviromental factors, such as viral infections might have an important influence. On the other hand, type 2 diabetes also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes. This type of diabetes may appear due to certain factors, such as older age, obesity, impaired glucose tolerance, family history of diabetes, physical inactivity, prior history of gestional diabetes and other factors. It has been considered that certain races and ethnicities, such as african americans, american indians, latino americans are more exposed to get type 2 diabetes than other people.

Gestional diabetes seem to occur in 2% to 5% of all pregnancies but the good thing is that usually disappears when the woman gives birth. Even though a woman who had suffered of gestional diabetes and healed when the pregnancy was over, might develop type 2 diabetes in the future.

Furthermore, there are other types of diabetes which may account for 1% to 2% of all known cases of diabetes and they occur from genetic syndroms, surgeries, drugs, malnutrition, infections and many other affections.

Medical treatments for diabetes are vital for the body and include important changes in the lifestyle. Diabetes treatments tend to adavance in a short time and their role is to maintain blood glucose near normal levels at all times. For instance, type 1 diabetes, the most severe type requires a wide range of procedures. People who suffer from this type of diabetes need a special treatment which include: administration of insulin injections, home blood glucose testing several times a day, a certain, calculated diet and also planned physical exercises. Even though, type 2 diabets is not so serios like type 1, it also requires a strict treatment which consists in special diets, physical activities, home blood glucose testing, oral medication and 40% of the cases require insulin injections.

The causes of type 1 diabetes are not entirely identified, it is believed that it occurs to genetics predisposition or certain viruses which destroy the beta cells in the pancreas. Some important factors which may develop type 2 diabetes are lack of activity and overweight.

In order to take care of the people who suffer from diabetes, the diabetes community offers, pursued by the US Departament of Health and Human Services offer three options: prevent diabetes, cure diabetes and moreover taking better care of people with diabetes to prevent dramatic complications. The National Institutes of Health (NIH) is involved in the research of curing type 1 and type 2 diabetes. On the other hand, Centers for Disease Control and Prevention focuses through their programmes on being sure that the proven science is put into daily practice for people with diabetes.

All in all, even though diabetes tends to be an incurable illness, the science try to discover and consequently to utilize in practice several methods to cure diabetes, such as pancreas transplantation, artificial pancreas development, islet cell transplantation and genetic manipulation. However, until these approaches become reality they need to pass through a serie of investigations like preventing immune rejection, finding an adequate number of insulin cells, keeping cells alive and many others.

So, if you want to find out more about type 2 diabetes or even about what causes diabetes please follow this link http://diabetes-info-center.com/



Thanks to Groshan Fabiola for contributing this article to our Diabetes blog:

New Treatment For Diabetes

This article will explain what you need to know about Diabetes before you or someone you know are unpleasantly surprised.

Diabetes affects around 16 million Americans and about 800,000 new cases are diagnosed each year.

A diagnosis of diabetes is made if your blood glucose reading is 126 mg/dl or higher. People with Type I Diabetes are subject to episodes in which blood glucose levels are very high (hyperglycemia) and very low (hypoglycemia). There are two primary reasons for Diabetes, 1) A prolonged diet high in carbohydrates and 2) Improper and under nourishment. Today, most people with diabetes are only treating the symptoms and not getting to the root of the problem. The prevalence of diabetes has been steadily increasing world over. Diabetes is a disease in which blood glucose levels are above normal.

Insulin is a hormone secreted by the pancreas that is needed to convert sugar and starches into energy needed for daily activity. Type 1 Diabetes is also called Insulin Dependent Diabetes. Insulin is a very important hormone that is needed to convert sugar, starches and other food into energy-the energy we need for daily life. Diabetes is a disease that develops over time, and your health care provider can help you find out whether you are likely to become a diabetic. Diabetes does not care who you are, if testing is painful or if you are tired. Type 2 diabetes is sometimes referred to as mature onset diabetes.

Type II diabetes, in the past, was relegated to the adult population. This form of diabetes is mainly found in children. Smoking is another important risk factor. Among men who smoke, the risk of developing diabetes is doubled. Of the many types of Diabetes, type 1 diabetes, type 2 diabetes, gestational. diabetes and pre-diabetes are the most common. Before the discovery of insulin, type 1 diabetes was fatal. Doing the right things to take care of diabetes can also help to take care of your heart as well. Most Type 2 diabetics don’t have symptoms because the onset. Typically, this type of diabetes will occur during the last three months of the pregnancy , but may potentially occur before that time.

Of the many types of Diabetes, type 1 diabetes, type 2 diabetes, gestational. Diabetes and pre-diabetes are the most common.

Twenty to fifty percent may develop Type 2 diabetes later in life. Children of mothers with gestational diabetes are more at risk for obesity and developing diabetes as teens or adults. It is quite possible to live and eat quite nicely with diabetes if you stick to your plan. The most important thing about dieting with diabetes is that you never lose sight of how crucial it is to do so. Through losing weight, getting the right amount of exercise and controlling your diet, you can manage. Juvenile Onset diabetes is another major form of diabetes that affects many children. The challenge with pre-diabetes is the fact that the condition doesn’t like to reveal itself with noticeable symptoms.

The experience teaches that a mere elimination of symptoms is short-lived, as the underlying causes will soon give birth to new symptoms. Diagnosed with type 2 Diabetes. One of the main causes is overweight. There are a number of causes which give rise to diabetes.

Recently more children are being diagnosed with Type 2 Diabetes. The aim with the treatment of both types of Diabetes is to have blood glucose levels, blood pressure and cholesterol levels as near to average as is possible.

You can prevent or at the very least delay onset of type II diabetes with proper nutrition and exercise.

The thought of getting a disease such as diabetes can be worrisome, it helps to be aware of what diabetes symptoms are and be able to recognize them early enough to get the help you will need to get the disease under control.

For people who are heavily dependent on medicines, exercise cannot replace drugs but it does contribute to normalizing the glucose metabolism.

There have been reports of women diabetics who experienced a decline in sexual activities due to the lack of sensation.

And most diabetics develop heart disease. Research has repeatedly shown that regular physical activity helps reduce the likelihood of having a heart attack or a stroke, aids in weight loss, and improves mood.

It is a very serious disorder, sometimes fatal and is the leading cause of death in Western society because of its damage to the cardiovascular system.

With exercise, weight loss and a healthy diet, pre-diabetic people can and have managed to bring down their glucose levels and have escaped the threat of an insulin-dependent life.

The cause of diabetes is somewhat a mystery, although both family history and environmental factors such as obesity and lack of exercise appear to play roles.

Ketoacidosis is most often seen in Type I diabetics, individuals whose pancreas does not produce enough insulin to allow their cells to take in glucose for metabolism (also the most common form of childhood diabetes).

It should come as no surprise that one of the major causes for the increase in diabetes is due to the obesity problem.

If proper treatment and medication is not administered, at times aggressively, it can lead to fatal complications .

In our days diabetes becomes a big problem even when patients are given insulin and stay on strict diets.

Doctors have always asked themselves why some people develop diabetes and some not, and so, by studying, they have discovered that there are some factors that interfere with the installation of diabetes.

As many studies have shown that an increase in UCP2 function has an important role in pathogenesis of diabetes, this genipin with its inhibitor action on UCP2, represents a solution for improving beta cell function in type 2 diabetes.



Thanks to Alexis-Blaise Kenne for contributing this article to our Diabetes blog:

Type 2 Diabetes Diet